Associate Principal Scientist, Preclinical Development

**Job Description**

As a Assoc Principal scientist, you will drive the creation of next-generation mammalian cell lines using a **systems-level approach** . You will be responsible for designing synthetic genetic circuits, managing large-scale multi-omics datasets, and utilizing Next-Generation Sequencing (NGS) to ensure the stability and productivity of therapeutic cell lines.

**Key Responsibilities**

+ **Cell Engineering & Synthetic Biology** : Design and optimize complex DNA vector constructs and synthetic gene circuits to enhance protein expression in CHO cells. Use cutting -edge gene-editing tools for targeted knock-in/out strategies.
+ **Systems Biology Integration** : Develop and apply computational models to understand cellular pathways and metabolism, predicting how genetic modifications impact global cell behavior and product quality.
+ **Big Data Analytics** : Build and maintain data pipelines to process high-dimensional datasets from hig...