Director/Senior Director, Admet (San Francisco Caballúa)

ResponsibilitiesModel Development: Build and validate predictive models across key ADMET and PK/PD endpoints (clearance, permeability, solubility, metabolic stability, DDI risk, transporter liabilities, exposure–toxicity relationships, and PK/PD) with mechanistic grounding and designed for partner use.Translational Modeling: Develop translational modeling approaches (PBPK, IVIVE, PK/PD simulation) to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across diverse programs and modalities.Distribution Modeling: Develop mechanistic and data‐driven models for tissue distribution, volume of distribution, plasma protein binding, and blood‐brain barrier penetration; calibrate across relevant species for human translatability.Partner Enablement & Usability: Translate ADMET/PK/PD science into practical, interpretable model outputs and workflows; create documentation, decision frameworks, and companion guidance for varying partner quantitative ...