Principal Scientist (Oncology / Metabolism) — Early Discovery Module Lead

Role Overview

The Principal Scientist serves as a module lead within the Early Discovery team, independently driving target biology research, early validation strategies, MOA hypothesis development, and target assessment. The role requires strong scientific judgment, project ownership, and effective communication with CROs and scientific collaborators. The successful candidate will also contribute scientific insights across projects and help strengthen best practices for early discovery.

Key Responsibilities

1. Independent Responsibilities (Core Tasks)

Target Discovery & Biological Rationale

• Independently evaluate novel targets using literature, public datasets (TCGA, DepMap, omics), internal data, and competitive intelligence.

• Build strong biological rationales, risk–benefit assessments, and mechanistic hypotheses.

• Propose target advancement strategies and deliver scientifically grounded go/no-go recommendations.