PhD position: Molecular research on BCL-2 & membrane contact sites

- Master’s degree in Pharmaceutical Science- Experience in:

Mammalian cell culture

Fluorescence microscopy of living cells for the analysis of time-resolved calcium signaling and organellar contact sites

Immunoblot analyses of cell samples

Autophagy and cell death analyses

Broader domain of neurodegenerative diseases

- Critical thinking and ability to think about experimental design, analyse data rigorously, and solve technical problems proactively.- Rigorous, organized and proactive with a collaborative mindset and enthusiasm to work in an international and interdisciplinary environment.- Proficiency in English, both spoken and written

Anti-apoptotic BCL-2 proteins enable cell survival by preventing mitochondrial BAX/BAK-pore formation and by preventing pro-apoptotic Ca2+-release from the endoplasmic reticulum (ER) (Vogler M et al, Signal Transduct Target Ther, 2025). Hematological cancers are addicted to BCL-2 for their survival by count...