Post-Doctoral Fellow - Myosin Phosphatase

*Post-doctoral research position in Division of Cardiology University of Maryland* A full time Post-Doctoral fellowship position is available in the laboratory of Dr. Steven Fisher in the Division of Cardiology at the University of Maryland-Baltimore as of April 1, 2019. The federally funded project examines vascular smooth muscle gene expression and contractility in the regulation of blood flow in development and disease models. The focus is on the myosin phosphatase (MP), a critical target of signals that regulate blood flow. Experiments will test the hypothesis that editing of MP lowers blood pressure in models of hypertension and heart failure, and will determine the mechanism(s) by which it does so. The post-doc will perform experiments in animal models using Cre-Lox and AAV-Crispr/Cas9 editing of MP in vivo. The AAV-Crispr/Cas9 approach of editing is in pre-clinical development as a novel therapy for humans with hypertension and heart failure. Applicants are required to have a Ph...