Postdoctoral Researcher in Human Neurovascular Cell Models

Postdoctoral Researcher in Human Neurovascular Cell Models

Nuffield Department of Clinical Neurosciences (NDCN), Dorothy Crowfoot Hodgkin Building, Sherrington Road, Oxford, OX1 3QU

The postholder will join the Cader Lab at the Kavli Institute for Nanoscience Discovery, University of Oxford, to lead experimental work for one of the key workpackages of the EU Innovation Council SECURE project, a major multi-partner programme developing self adaptive gene therapies for neurological disease.

This will involve (1) producing a single nuclei atlas of the substantia nigra and (2) developing and applying advanced human iPSC-derived blood–brain barrier (BBB) models to evaluate next‑generation CNS‑targeted viral vectors. The successful candidate will use models to assess vector transcytosis and tropism in both healthy and disease contexts. The work will generate human‑relevant data on BBB permeability, receptor expression and transcriptomic signatures that will dire...