Opportunity Description
We are seeking a highly motivated and creative Research Fellow to join our team and lead an exciting project on how biomolecular condensates regulate enzyme function. We use quantitative single-molecule approaches to link enzyme structure, dynamics, and kinetics in both condensate and dilute environments. By integrating complementary measurements across timescales, we investigate conformational state switching, reaction dynamics under non-equilibrium conditions, and molecular mobility and permeability within dense phases.
Responsibilities:
Research Leadership: Spearhead an independent project decoding how biomolecular condensates regulate enzyme function .
Tool Engineering: Design and validate novel molecular probes or synthetic condensates, leveraging genetic engineering or generative protein design.
Data acquisition: Apply advanced single-molecule spectroscopy methods to measure molecular dynamics in vitro and in cell.
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